July 12, 2016
Post-transplant Upkeep TKIs Helpful when it come to Patients Along with High-threat Ph+ Leukemia
How procedure Along with posttransplant Upkeep tyrosine kinase inhibitors (TKIs) impacts allogeneic hematopoietic stem cell transplantation when it come to patients Along with high-threat Philly chromosome-good (Ph+) leukemia is no longer totally understood. Researchers, based at the Winship Cancer Institute, Emory University, Atlanta, sought to identify the impact of TKI treatment when it come to this patient group.
The investigators complied with the development of 2six patients complete (17 patients Along with Ph+ acute lymphoblastic leukemia and 9 patients Along with chronic myeloid leukemia) that obtained Upkeep posttransplant therapy. The patients were treated Along with dasatinib, imatinib, nilotinib, or ponatinib, and procedure took position in the 10-year interval from 2004 with 2014. TKI treatment was started a median of one hundred days adhering to transplantation and the duration of treatment was 1six months (median).
TKI choice was motivated based on estimated toxicities, pretransplantation response, and ABL1 domain mutations, if any. The median follow-up interval was 3.six years. The patient relapse-complimentary survival price was 61% after a 5-year period, and the general survival price was 78%. The three patients that subsequently suffered relapse were located to be disease-complimentary after effective recover treatment.
The Study group ended that TKI treatment adhering to allogeneic hematopoietic stem cell transplantation might be beneficial, cutting down the lot of relapses when it come to patients Along with progressed Ph+ leukemia.
Reference
1. DeFilipp Z, Langston A, Chen Z, et al. Does post-transplant Upkeep treatment Along with tyrosine kinase inhibitors boost outcomes of patients Along with high-threat Philly chromosome-good leukemia? Clin Lymphoma Myeloma Leuk. 2016. doi: 10.1016/j.clml.2016.04.017. [Epub ahead of print]
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